APOL1 renal-risk variants induce mitochondrial dysfunction
L Ma, JW Chou, JA Snipes, MS Bharadwaj… - Journal of the …, 2017 - journals.lww.com
Abstract APOL1 G1 and G2 variants facilitate kidney disease in blacks. To elucidate the
pathways whereby these variants contribute to disease pathogenesis, we established
HEK293 cell lines stably expressing doxycycline-inducible (Tet-on) reference APOL1 G0 or
the G1 and G2 renal-risk variants, and used Illumina human HT-12 v4 arrays and Affymetrix
HTA 2.0 arrays to generate global gene expression data with doxycycline induction.
Significantly altered pathways identified through bioinformatics analyses involved …
pathways whereby these variants contribute to disease pathogenesis, we established
HEK293 cell lines stably expressing doxycycline-inducible (Tet-on) reference APOL1 G0 or
the G1 and G2 renal-risk variants, and used Illumina human HT-12 v4 arrays and Affymetrix
HTA 2.0 arrays to generate global gene expression data with doxycycline induction.
Significantly altered pathways identified through bioinformatics analyses involved …