Potassium activates mTORC2-dependent SGK1 phosphorylation to stimulate epithelial sodium channel: role in rapid renal responses to dietary potassium
Background Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+].
However, the underlying cellular and molecular mechanisms that are relevant in vivo for
these responses remain controversial. Methods We used Cre-Lox–mediated knockout of
rapamycin-insensitive companion of TOR (Rictor) to inactivate mTORC2 in kidney tubule
cells of mice. In a series of time-course experiments in wild-type and knockout mice, we …
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+].
However, the underlying cellular and molecular mechanisms that are relevant in vivo for
these responses remain controversial. Methods We used Cre-Lox–mediated knockout of
rapamycin-insensitive companion of TOR (Rictor) to inactivate mTORC2 in kidney tubule
cells of mice. In a series of time-course experiments in wild-type and knockout mice, we …
Potassium activates mTORC2-dependent SGK1 phosphorylation to stimulate ENaC: role in rapid renal responses to dietary potassium
BACKGROUND: Increasing evidence implicates the signaling kinase mTOR complex-2
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+].
However, the underlying cellular and molecular mechanisms that are relevant in vivo for
these responses remain controversial. METHODS: We used Cre-Lox-mediated knockout of
rapamycin-insensitive companion of TOR (Rictor) to inactivate mTORC2 in kidney tubule
cells of mice. In a series of time-course experiments in wild-type and knockout mice, we …
(mTORC2) in rapid renal responses to changes in plasma potassium concentration [K+].
However, the underlying cellular and molecular mechanisms that are relevant in vivo for
these responses remain controversial. METHODS: We used Cre-Lox-mediated knockout of
rapamycin-insensitive companion of TOR (Rictor) to inactivate mTORC2 in kidney tubule
cells of mice. In a series of time-course experiments in wild-type and knockout mice, we …