[HTML][HTML] The diagnostic and clinical utility of microbial cell-free DNA sequencing in a real-world setting
Microbial cell free DNA sequencing is increasingly used for diagnosis of infection but few
studies describe its utility in real-world settings. We performed a single-center retrospective
case series of microbial cell free DNA testing using the Karius assay from 29 patient
samples to define the clinical reasoning and the impact of testing. Indications fell into 3
categories, identifying a causative pathogen in patients with an infectious syndrome and
negative microbiologic workup (15/29, 52%), seeking another pathogen when organisms …
studies describe its utility in real-world settings. We performed a single-center retrospective
case series of microbial cell free DNA testing using the Karius assay from 29 patient
samples to define the clinical reasoning and the impact of testing. Indications fell into 3
categories, identifying a causative pathogen in patients with an infectious syndrome and
negative microbiologic workup (15/29, 52%), seeking another pathogen when organisms …