Effect of metformin vs placebo on invasive disease–free survival in patients with breast cancer: the MA. 32 randomized clinical trial
PJ Goodwin, BE Chen, KA Gelmon, TJ Whelan… - Jama, 2022 - jamanetwork.com
Importance Metformin, a biguanide commonly used to treat type 2 diabetes, has been
associated with potential beneficial effects across breast cancer subtypes in observational
and preclinical studies. Objective To determine whether the administration of adjuvant
metformin (vs placebo) to patients with breast cancer without diabetes improves outcomes.
Design, Setting, and Participants MA. 32, a phase 3 randomized, placebo-controlled, double-
blind trial, conducted in Canada, Switzerland, US, and UK, enrolled 3649 patients with high …
associated with potential beneficial effects across breast cancer subtypes in observational
and preclinical studies. Objective To determine whether the administration of adjuvant
metformin (vs placebo) to patients with breast cancer without diabetes improves outcomes.
Design, Setting, and Participants MA. 32, a phase 3 randomized, placebo-controlled, double-
blind trial, conducted in Canada, Switzerland, US, and UK, enrolled 3649 patients with high …