Predictive utility of a coronary artery disease polygenic risk score in primary prevention
NA Marston, JP Pirruccello, GEM Melloni… - JAMA …, 2023 - jamanetwork.com
Importance The clinical utility of polygenic risk scores (PRS) for coronary artery disease
(CAD) has not yet been established. Objective To investigate the ability of a CAD PRS to
potentially guide statin initiation in primary prevention after accounting for age and clinical
risk. Design, Setting, and Participants This was a longitudinal cohort study with enrollment
starting on January 1, 2006, and ending on December 31, 2010, with data updated to mid-
2021, using data from the UK Biobank, a long-term population study of UK citizens. A …
(CAD) has not yet been established. Objective To investigate the ability of a CAD PRS to
potentially guide statin initiation in primary prevention after accounting for age and clinical
risk. Design, Setting, and Participants This was a longitudinal cohort study with enrollment
starting on January 1, 2006, and ending on December 31, 2010, with data updated to mid-
2021, using data from the UK Biobank, a long-term population study of UK citizens. A …