[HTML][HTML] PCSK9 SNP rs11591147 is associated with low cholesterol levels but not with cognitive performance or noncardiovascular clinical events in an elderly …
I Postmus, S Trompet, AJM de Craen, BM Buckley… - Journal of lipid …, 2013 - ASBMB
Proprotein convertase subtilisin-like/kexin type 9 (PCSK9) is a protein involved in LDL-
cholesterol metabolism. The single-nucleotide polymorphism (SNP) rs11591147 has been
associated with lower LDL-cholesterol and a lower risk of coronary heart disease. Because
PCSK9 has high affinity to the LDL receptor, inhibiting PCSK9 is a testable therapeutic target
for lipid-lowering therapy. Currently, several approaches to inhibit PCSK9 are under
development, but it is unknown what the effects of those inhibitors will be on cognition or …
cholesterol metabolism. The single-nucleotide polymorphism (SNP) rs11591147 has been
associated with lower LDL-cholesterol and a lower risk of coronary heart disease. Because
PCSK9 has high affinity to the LDL receptor, inhibiting PCSK9 is a testable therapeutic target
for lipid-lowering therapy. Currently, several approaches to inhibit PCSK9 are under
development, but it is unknown what the effects of those inhibitors will be on cognition or …