Palindromic gene amplification—an evolutionarily conserved role for DNA inverted repeats in the genome
The clinical importance of gene amplification in the diagnosis and treatment of cancer has
been widely recognized, as it is often evident in advanced stages of diseases. However, our
knowledge of the underlying mechanisms is still limited. Gene amplification is an essential
process in several organisms including the ciliate Tetrahymena thermophila, in which the
initiating mechanism has been well characterized. Lessons from such simple eukaryotes
may provide useful information regarding how gene amplification occurs in tumour cells.
been widely recognized, as it is often evident in advanced stages of diseases. However, our
knowledge of the underlying mechanisms is still limited. Gene amplification is an essential
process in several organisms including the ciliate Tetrahymena thermophila, in which the
initiating mechanism has been well characterized. Lessons from such simple eukaryotes
may provide useful information regarding how gene amplification occurs in tumour cells.
Abstract
The clinical importance of gene amplification in the diagnosis and treatment of cancer has been widely recognized, as it is often evident in advanced stages of diseases. However, our knowledge of the underlying mechanisms is still limited. Gene amplification is an essential process in several organisms including the ciliate Tetrahymena thermophila, in which the initiating mechanism has been well characterized. Lessons from such simple eukaryotes may provide useful information regarding how gene amplification occurs in tumour cells.
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