Femtosecond optical ranging in biological systems
JG Fujimoto, S De Silvestri, EP Ippen, CA Puliafito… - Optics letters, 1986 - opg.optica.org
JG Fujimoto, S De Silvestri, EP Ippen, CA Puliafito, R Margolis, A Oseroff
Optics letters, 1986•opg.optica.orgOptical ranging using femtosecond laser pulses and nonlinear-optical cross correlation is
demonstrated for the investigation of the microstructure of biological systems. By using
pulses of 65-fsec duration generated by a colliding-pulse mode-locked ring dye laser, a
spatial resolution of less than 15 μm is achieved with a detection sensitivity to remitted
signals as small as 10^− 7 of the incident pulse energy. This technique is applied to
measure the cornea in rabbit eyes in vivo as well as to investigate the epidermal structure of …
demonstrated for the investigation of the microstructure of biological systems. By using
pulses of 65-fsec duration generated by a colliding-pulse mode-locked ring dye laser, a
spatial resolution of less than 15 μm is achieved with a detection sensitivity to remitted
signals as small as 10^− 7 of the incident pulse energy. This technique is applied to
measure the cornea in rabbit eyes in vivo as well as to investigate the epidermal structure of …
Optical ranging using femtosecond laser pulses and nonlinear-optical cross correlation is demonstrated for the investigation of the microstructure of biological systems. By using pulses of 65-fsec duration generated by a colliding-pulse mode-locked ring dye laser, a spatial resolution of less than 15 μm is achieved with a detection sensitivity to remitted signals as small as 10^−7 of the incident pulse energy. This technique is applied to measure the cornea in rabbit eyes in vivo as well as to investigate the epidermal structure of human skin in vitro.
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