Inflammasome Signaling in Atrial Fibrillation: JACC State-of-the-Art Review
Journal of the American College of Cardiology, 2022•jacc.org
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in
patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis
and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3
inflammasome activation contributes to onset and progression of AF. Herein, the authors aim
at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis …
failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in
patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis
and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3
inflammasome activation contributes to onset and progression of AF. Herein, the authors aim
at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis …
Abstract
As the most prevalent form of arrhythmia, atrial fibrillation (AF) increases the risk of heart failure, thromboembolism, and stroke, contributing to the raising mortality and morbidity in patients with cardiovascular diseases. Despite the multifaceted nature of AF pathogenesis and complexity of AF pathophysiology, a growing body of evidence indicates that the NLRP3 inflammasome activation contributes to onset and progression of AF. Herein, the authors aim at reviewing the current literature on the role of inflammasome signaling in AF pathogenesis, and novel therapeutic options in the management of AF.
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