Increasing complexity of the dystrophin-associated protein complex.
JM Tinsley, DJ Blake, RA Zuellig… - Proceedings of the …, 1994 - National Acad Sciences
Proceedings of the National Academy of Sciences, 1994•National Acad Sciences
Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease
caused by lack of the protein dystrophin. The exact function of dystrophin remains to be
determined. However, analysis of its interaction with a large oligomeric protein complex at
the sarcolemma and the identification of a structurally related protein, utrophin, is leading to
the characterization of candidate genes for other neuromuscular disorders.
caused by lack of the protein dystrophin. The exact function of dystrophin remains to be
determined. However, analysis of its interaction with a large oligomeric protein complex at
the sarcolemma and the identification of a structurally related protein, utrophin, is leading to
the characterization of candidate genes for other neuromuscular disorders.
Duchenne muscular dystrophy is a severe X chromosome-linked, muscle-wasting disease caused by lack of the protein dystrophin. The exact function of dystrophin remains to be determined. However, analysis of its interaction with a large oligomeric protein complex at the sarcolemma and the identification of a structurally related protein, utrophin, is leading to the characterization of candidate genes for other neuromuscular disorders.
National Acad Sciences
