LIM-domain-only proteins: multifunctional nuclear transcription coregulators that interacts with diverse proteins
M Sang, L Ma, M Sang, X Zhou, W Gao… - Molecular biology reports, 2014 - Springer
M Sang, L Ma, M Sang, X Zhou, W Gao, C Geng
Molecular biology reports, 2014•SpringerThe LIM-only subclass of LIM proteins is a family of nuclear transcription co-regulators that
are characterized by the exclusive presence of two tandem LIM domains and no other
functional domains. To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been
identified. They regulate gene transcription by functioning as “linker” or “scaffolding” proteins
with a remarkable potential to mediate protein–protein interactions. These proteins play
important roles in cell fate determination, cell growth and differentiation, tissues patterning …
are characterized by the exclusive presence of two tandem LIM domains and no other
functional domains. To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been
identified. They regulate gene transcription by functioning as “linker” or “scaffolding” proteins
with a remarkable potential to mediate protein–protein interactions. These proteins play
important roles in cell fate determination, cell growth and differentiation, tissues patterning …
Abstract
The LIM-only subclass of LIM proteins is a family of nuclear transcription co-regulators that are characterized by the exclusive presence of two tandem LIM domains and no other functional domains. To date, four LIM-domain-only (LMO) proteins (LMO1-LMO4) have been identified. They regulate gene transcription by functioning as “linker” or “scaffolding” proteins with a remarkable potential to mediate protein–protein interactions. These proteins play important roles in cell fate determination, cell growth and differentiation, tissues patterning, and organ development. In this review, we briefly described the functions of LMO proteins in the organ development and diseases. We also summarized the interaction proteins of each LMO family member, which may contribute to elucidating the functions of these mysterious and important linker proteins.
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