[HTML][HTML] LMO1 Gene Polymorphisms Reduce Neuroblastoma Risk in Eastern Chinese Children: A Three-Center Case-Control Study
L He, J Zhu, F Han, Y Tang, C Zhou, J Dai… - Frontiers in …, 2018 - frontiersin.org
Frontiers in Oncology, 2018•frontiersin.org
Background: Neuroblastoma, a neuroendocrine tumor, stems from the developing
sympathetic nervous system. Previous genome-wide association studies (GWASs) have
discovered a number of neuroblastoma susceptibility genes in Caucasians including LIM
domain only 1 (LMO1). Objective: We conducted a three-center case-control study including
313 cases and 716 controls with the purpose to evaluate the association between five
GWAS-identified LMO1 variants (rs110419 A> G, rs4758051 G> A, rs10840002 A> G …
sympathetic nervous system. Previous genome-wide association studies (GWASs) have
discovered a number of neuroblastoma susceptibility genes in Caucasians including LIM
domain only 1 (LMO1). Objective: We conducted a three-center case-control study including
313 cases and 716 controls with the purpose to evaluate the association between five
GWAS-identified LMO1 variants (rs110419 A> G, rs4758051 G> A, rs10840002 A> G …
Background: Neuroblastoma, a neuroendocrine tumor, stems from the developing sympathetic nervous system. Previous genome-wide association studies (GWASs) have discovered a number of neuroblastoma susceptibility genes in Caucasians including LIM domain only 1 (LMO1).
Objective: We conducted a three-center case-control study including 313 cases and 716 controls with the purpose to evaluate the association between five GWAS-identified LMO1 variants (rs110419 A>G, rs4758051 G>A, rs10840002 A>G, rs204938 A>G, and rs2168101 G>T) and neuroblastoma susceptibility in eastern Chinese children.
Methods: Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated to evaluate the strength of the associations. False positive report possibility (FPRP) analysis was performed to check whether significant results were noteworthy.
Results: Significant associations with neuroblastoma risk were found for four (rs110419, rs4758051, rs10840002, and rs2168101) out of the five polymorphisms. Combined analysis demonstrated that carriers of 4–5 protective genotypes had a significantly decreased risk of neuroblastoma in comparison those with 0–3 protective genotypes (adjusted OR = 0.51, 95% CI = 0.39–0.68, P < 0.0001). Haplotype analysis of the five SNPs yield four significant haplotypes associated with neuroblastoma susceptibility.
Conclusion: In conclusion, we confirmed LMO1 polymorphisms may reduce neuroblastoma risk in eastern Chinese populations.
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