Is cystic fibrosis a TH17 disease?
PJ Dubin, F McAllister, JK Kolls - Inflammation Research, 2007 - Springer
PJ Dubin, F McAllister, JK Kolls
Inflammation Research, 2007•SpringerCystic Fibrosis (CF) is the most common lethal genetic disease in the Caucasian population
and typically results in the development of bronchial inflammation, bronchiectasis, the
progressive loss of lung function and ultimately death. Recently it has been shown that
products of the Th 17 subset of T-cells, specifically, IL-17A and IL-17F are elevated in the
sputum of CF patients. This review will go over experimental evidence supporting a role for
the IL-23/IL-17 axis in CF lung inflammation.
and typically results in the development of bronchial inflammation, bronchiectasis, the
progressive loss of lung function and ultimately death. Recently it has been shown that
products of the Th 17 subset of T-cells, specifically, IL-17A and IL-17F are elevated in the
sputum of CF patients. This review will go over experimental evidence supporting a role for
the IL-23/IL-17 axis in CF lung inflammation.
Abstract
Cystic Fibrosis (CF) is the most common lethal genetic disease in the Caucasian population and typically results in the development of bronchial inflammation, bronchiectasis, the progressive loss of lung function and ultimately death. Recently it has been shown that products of the Th17 subset of T-cells, specifically, IL-17A and IL-17F are elevated in the sputum of CF patients. This review will go over experimental evidence supporting a role for the IL- 23/IL-17 axis in CF lung inflammation.
Springer
