The effect of regulatory T cells on tolerance to airborne allergens and allergen immunotherapy
P Bacher, A Scheffold - Journal of Allergy and Clinical Immunology, 2018 - Elsevier
Forkhead box P3–positive regulatory T (Treg) cells are essential mediators of tolerance
against self-antigens and harmless exogenous antigens. Treg cell deficiencies result in
multiple autoimmune and allergic syndromes in neonates. How Treg cells affect
conventional allergies against aeroantigens, which are restricted to a few specific proteins
released from inhaled particles, remains controversial. The hallmarks of antigen-specific
loss of tolerance are allergen-specific TH 2 cells and IgE. However, difficulties in identifying …
against self-antigens and harmless exogenous antigens. Treg cell deficiencies result in
multiple autoimmune and allergic syndromes in neonates. How Treg cells affect
conventional allergies against aeroantigens, which are restricted to a few specific proteins
released from inhaled particles, remains controversial. The hallmarks of antigen-specific
loss of tolerance are allergen-specific TH 2 cells and IgE. However, difficulties in identifying …
