Location matters: hexokinase 1 in glucose metabolism and inflammation
Trends in Endocrinology & Metabolism, 2022•cell.com
Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological
relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying
mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1
localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute
to the inflammation associated with diabetes and aging.
relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying
mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1
localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute
to the inflammation associated with diabetes and aging.
Hexokinase (HK)-1 mitochondrial-binding mechanisms and consequential physiological relevance remain unclear. Recently, De Jesus et al. studied myeloid cells with HK1 carrying mutated mitochondrial-binding domains (MBDs) and provided evidence that HK1 localization controls glucose metabolic fate. Increases in cytosolic HK1 may also contribute to the inflammation associated with diabetes and aging.
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