Antimicrobial activity of Substance P and Neuropeptide Y against laboratory strains of bacteria and oral microorganisms
CJ Hansen, KK Burnell, KA Brogden - Journal of neuroimmunology, 2006 - Elsevier
Infection and inflammation of mucosal tissue may induce the production of neuropeptides,
specifically Substance P and Neuropeptide Y. Since these neuropeptides are similar to
antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge,
and size, we wanted to determine if they had antimicrobial activity against a panel of
common bacteria and oral microorganisms using the radial diffusion assay. Neuropeptide Y
and Substance P had antimicrobial activity against E. coli (MIC 20.6±5.5 μg/ml SEM and …
specifically Substance P and Neuropeptide Y. Since these neuropeptides are similar to
antimicrobial peptides in their amino acid composition, amphipathic design, cationic charge,
and size, we wanted to determine if they had antimicrobial activity against a panel of
common bacteria and oral microorganisms using the radial diffusion assay. Neuropeptide Y
and Substance P had antimicrobial activity against E. coli (MIC 20.6±5.5 μg/ml SEM and …