[HTML][HTML] The mitochondrial unfolded protein response as a non-oncogene addiction to support adaptation to stress during transformation in cancer and beyond
TC Kenny, G Manfredi, D Germain - Frontiers in oncology, 2017 - frontiersin.org
TC Kenny, G Manfredi, D Germain
Frontiers in oncology, 2017•frontiersin.orgUpon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded
protein response (UPRmt) is activated. This review focuses on the role of this response in
cancer. We discuss evidence that during transformation, the UPRmt may play an essential
role in the maintenance of the integrity of the mitochondria in the face of increased oxidative
stress. However, the role of the UPRmt in other diseases is also emerging and is therefore
also briefly discussed.
protein response (UPRmt) is activated. This review focuses on the role of this response in
cancer. We discuss evidence that during transformation, the UPRmt may play an essential
role in the maintenance of the integrity of the mitochondria in the face of increased oxidative
stress. However, the role of the UPRmt in other diseases is also emerging and is therefore
also briefly discussed.
Upon accumulation of misfolded proteins in the mitochondria, the mitochondrial unfolded protein response (UPRmt) is activated. This review focuses on the role of this response in cancer. We discuss evidence that during transformation, the UPRmt may play an essential role in the maintenance of the integrity of the mitochondria in the face of increased oxidative stress. However, the role of the UPRmt in other diseases is also emerging and is therefore also briefly discussed.
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