Janus kinase inhibition for immunosuppression in solid organ transplantation: Is there a role in complex immunologic challenges?
CA Moore, CJ Iasella, R Venkataramanan, FG Lakkis… - Human Immunology, 2017 - Elsevier
Inhibition of the Janus kinase-signal transducer and activator of transcription (JAK-STAT)
pathway for immunosuppression in solid organ transplantation is appealing due to its
specificity for immune cell function, particularly for JAK3. This is due to its unique association
with only the common gamma chain (γ c). The γ c is an appealing immunosuppression
target in transplantation because of the critically important lymphokines that act at it,
including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Tofacitinib was initially purported to …
pathway for immunosuppression in solid organ transplantation is appealing due to its
specificity for immune cell function, particularly for JAK3. This is due to its unique association
with only the common gamma chain (γ c). The γ c is an appealing immunosuppression
target in transplantation because of the critically important lymphokines that act at it,
including IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21. Tofacitinib was initially purported to …