Donor-specific HLA alloantibodies: impact on cardiac allograft vasculopathy, rejection, and survival after pediatric heart transplantation
A Tran, D Fixler, R Huang, T Meza, C Lacelle… - The Journal of Heart and …, 2016 - Elsevier
Background There is increasing evidence that donor-specific anti-HLA antibodies (DSA) are
associated with poor outcomes after cardiac transplantation in adults, but data are limited in
children. The objective of this study was to examine the development and consequences of
de novo DSA in pediatric recipients of heart transplants. Methods We analyzed 105 pediatric
patients who received heart transplants at our center from January 2002 to December 2012.
All patients had negative T-cell and B-cell post-transplant crossmatches. Patients underwent …
associated with poor outcomes after cardiac transplantation in adults, but data are limited in
children. The objective of this study was to examine the development and consequences of
de novo DSA in pediatric recipients of heart transplants. Methods We analyzed 105 pediatric
patients who received heart transplants at our center from January 2002 to December 2012.
All patients had negative T-cell and B-cell post-transplant crossmatches. Patients underwent …