[HTML][HTML] Blockade of p-selectin is sufficient to reduce MHC I antibody-elicited monocyte recruitment in vitro and in vivo
NM Valenzuela, L Hong, F Gao, SH Young… - American journal of …, 2013 - Elsevier
Donor-specific HLA antibodies significantly lower allograft survival, but as yet there are no
satisfactory therapies for prevention of antibody-mediated rejection. Intracapillary
macrophage infiltration is a hallmark of antibody-mediated rejection, and macrophages are
important in both acute and chronic rejection. The purpose of this study was to investigate
the Fc-independent effect of HLA I antibodies on endothelial cell activation, leading to
monocyte recruitment. We used an in vitro model to assess monocyte binding to endothelial …
satisfactory therapies for prevention of antibody-mediated rejection. Intracapillary
macrophage infiltration is a hallmark of antibody-mediated rejection, and macrophages are
important in both acute and chronic rejection. The purpose of this study was to investigate
the Fc-independent effect of HLA I antibodies on endothelial cell activation, leading to
monocyte recruitment. We used an in vitro model to assess monocyte binding to endothelial …