Correlations of lymphocyte subset infiltrates with donor-specific antibodies and acute antibody-mediated rejection in endomyocardial biopsies
R Frank, SA Dean, MR Molina, M Kamoun… - Cardiovascular …, 2015 - Elsevier
Background Acute antibody-mediated rejection (AMR) is a major complication after heart
transplantation, posing a significant risk for allograft failure, cardiac allograft vasculopathy,
and poor survival. While the inflammatory milieu of cellular rejection and Quilty lesions is
well known, the immunologic components of AMR are not well understood. Our aim was to
better define the immunophenotype of infiltrating lymphocytes in biopsies with AMR,
specifically in relation to donor-specific antibodies to human leukocyte antigen (HLA) class I …
transplantation, posing a significant risk for allograft failure, cardiac allograft vasculopathy,
and poor survival. While the inflammatory milieu of cellular rejection and Quilty lesions is
well known, the immunologic components of AMR are not well understood. Our aim was to
better define the immunophenotype of infiltrating lymphocytes in biopsies with AMR,
specifically in relation to donor-specific antibodies to human leukocyte antigen (HLA) class I …