[HTML][HTML] Cistrome-based cooperation between airway epithelial glucocorticoid receptor and NF-κB orchestrates anti-inflammatory effects
V Kadiyala, SK Sasse, MO Altonsy, R Berman… - Journal of Biological …, 2016 - ASBMB
Antagonism of pro-inflammatory transcription factors by monomeric glucocorticoid receptor
(GR) has long been viewed as central to glucocorticoid (GC) efficacy. However, the
mechanisms and targets through which GCs exert therapeutic effects in diseases such as
asthma remain incompletely understood. We previously defined a surprising cooperative
interaction between GR and NF-κB that enhanced expression of A20 (TNFAIP3), a potent
inhibitor of NF-κB. Here we extend this observation to establish that A20 is required for …
(GR) has long been viewed as central to glucocorticoid (GC) efficacy. However, the
mechanisms and targets through which GCs exert therapeutic effects in diseases such as
asthma remain incompletely understood. We previously defined a surprising cooperative
interaction between GR and NF-κB that enhanced expression of A20 (TNFAIP3), a potent
inhibitor of NF-κB. Here we extend this observation to establish that A20 is required for …