Hepatic ceramides dissociate steatosis and insulin resistance in patients with non-alcoholic fatty liver disease
PK Luukkonen, Y Zhou, S Sädevirta, M Leivonen… - Journal of …, 2016 - Elsevier
Background & Aims Recent data in mice have identified de novo ceramide synthesis as the
key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in
liver fat due to IR ('Metabolic NAFLD'but not that due to the I148M gene variant in PNPLA3
('PNPLA3 NAFLD'). We determined which bioactive lipids co-segregate with IR in the human
liver. Methods Liver lipidome was profiled in liver biopsies from 125 subjects that were
divided into equally sized groups based on median HOMA-IR ('High and Low HOMA-IR', n …
key mediator of hepatic insulin resistance (IR) that in humans characterizes increases in
liver fat due to IR ('Metabolic NAFLD'but not that due to the I148M gene variant in PNPLA3
('PNPLA3 NAFLD'). We determined which bioactive lipids co-segregate with IR in the human
liver. Methods Liver lipidome was profiled in liver biopsies from 125 subjects that were
divided into equally sized groups based on median HOMA-IR ('High and Low HOMA-IR', n …