Pathophysiological roles for purines: adenosine, caffeine and urate
M Morelli, AR Carta, A Kachroo… - Progress in brain …, 2010 - Elsevier
The motor symptoms of Parkinson's disease (PD) are primarily due to the degeneration of
the dopaminergic neurons in the nigrostriatal pathway. However, several other brain areas
and neurotransmitters other than dopamine such as noradrenaline, 5-hydroxytryptamine
and acetylcholine are affected in the disease. Moreover, adenosine because of the
extensive interaction of its receptors with the dopaminergic system has been implicated in
the pathophysiology of the disease. Based on the involvement of these non-dopaminergic …
the dopaminergic neurons in the nigrostriatal pathway. However, several other brain areas
and neurotransmitters other than dopamine such as noradrenaline, 5-hydroxytryptamine
and acetylcholine are affected in the disease. Moreover, adenosine because of the
extensive interaction of its receptors with the dopaminergic system has been implicated in
the pathophysiology of the disease. Based on the involvement of these non-dopaminergic …