Striatal G-proteins: effects of unilateral 6-hydroxydopamine lesions
ER Marcotte, RM Sullivan, RK Mishra - Neuroscience letters, 1994 - Elsevier
ER Marcotte, RM Sullivan, RK Mishra
Neuroscience letters, 1994•ElsevierTo investigate the molecular mechanisms of denervation-induced dopamine receptor
supersensitivity, levels of striatal G-proteins were examined in 6-hydroxydopamine (6-
OHDA)-lesioned rats. Increased levels of the α-subunits of G s and G olf, as measured by
immunoblotting, were observed 8 days postlesion and remained elevated up to day 28 (25–
45% over the time course). G i levels were significantly increased only on day 8 (20%) and G
o levels remained unaltered. These results suggest that stimulatory G-proteins may be …
supersensitivity, levels of striatal G-proteins were examined in 6-hydroxydopamine (6-
OHDA)-lesioned rats. Increased levels of the α-subunits of G s and G olf, as measured by
immunoblotting, were observed 8 days postlesion and remained elevated up to day 28 (25–
45% over the time course). G i levels were significantly increased only on day 8 (20%) and G
o levels remained unaltered. These results suggest that stimulatory G-proteins may be …
Abstract
To investigate the molecular mechanisms of denervation-induced dopamine receptor supersensitivity, levels of striatal G-proteins were examined in 6-hydroxydopamine (6-OHDA)-lesioned rats. Increased levels of the α-subunits of Gs and Golf, as measured by immunoblotting, were observed 8 days postlesion and remained elevated up to day 28 (25–45% over the time course). Gi levels were significantly increased only on day 8 (20%) and Go levels remained unaltered. These results suggest that stimulatory G-proteins may be involved in the long-term maintenance of dopamine receptor supersensitivity following denervation.
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