Quantitative real-time RT-PCR assessment of spinal microglial and astrocytic activation markers in a rat model of neuropathic pain
FY Tanga, V Raghavendra, JA DeLeo - Neurochemistry international, 2004 - Elsevier
Activated spinal glial cells have been strongly implicated in the development and
maintenance of persistent pain states following a variety of stimuli including traumatic nerve
injury. The present study was conducted to characterize the time course of surface markers
indicative of microglial and astrocytic activation at the transcriptional level following an L5
nerve transection that results in behavioral hypersensitivity. Male Sprague-Dawley rats were
divided into a normal group, a sham surgery group with an L5 spinal nerve exposure and an …
maintenance of persistent pain states following a variety of stimuli including traumatic nerve
injury. The present study was conducted to characterize the time course of surface markers
indicative of microglial and astrocytic activation at the transcriptional level following an L5
nerve transection that results in behavioral hypersensitivity. Male Sprague-Dawley rats were
divided into a normal group, a sham surgery group with an L5 spinal nerve exposure and an …