[HTML][HTML] Unfolded protein response signaling and metabolic diseases
J Lee, U Ozcan - Journal of Biological Chemistry, 2014 - ASBMB
The endoplasmic reticulum (ER) is a central organelle for protein biosynthesis, folding, and
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to
activation of the complex signaling cascade called the unfolded protein response (UPR).
Recent studies have documented that the UPR coordinates multiple signaling pathways and
controls various physiologies in cells and the whole organism. Furthermore, unresolved ER
stress has been implicated in a variety of metabolic disorders, such as obesity and type 2 …
traffic. Perturbations in ER homeostasis create a condition termed ER stress and lead to
activation of the complex signaling cascade called the unfolded protein response (UPR).
Recent studies have documented that the UPR coordinates multiple signaling pathways and
controls various physiologies in cells and the whole organism. Furthermore, unresolved ER
stress has been implicated in a variety of metabolic disorders, such as obesity and type 2 …