Prostaglandins (PGs) and nitric oxide (NO) may be involved in the pathophysiology of
depression. Since NSAIDs decrease PGs and NO production, they may have an
antidepressant effect. The aim of the present work was to explore a possible antidepressant
action of ibuprofen in the new model of Bacillus Calmette–Guerin (BCG) induced
depression. Mice injected with BCG (10 7 CFU/mouse intraperitoneally) showed an increase
in the total immobility time during the forced swim test (FST) and the tail suspension test …