Mdm2 binds to Nbs1 at sites of DNA damage and regulates double strand break repair
JR Alt, A Bouska, MR Fernandez, RL Cerny… - Journal of Biological …, 2005 - ASBMB
Mdm2 directly regulates the p53 tumor suppressor. However, Mdm2 also has p53-
independent activities, and the pathways that mediate these functions are unresolved. Here
we report the identification of a specific association of Mdm2 with Mre11, Nbs1, and Rad50,
a DNA double strand break repair complex. Mdm2 bound to the Mre11-Nbs1-Rad50
complex in primary cells and in cells containing inactivated p53 or p14/p19 ARF, a regulator
of Mdm2. Further analysis revealed that Mdm2 directly bound to Nbs1 but not to Mre11 or …
independent activities, and the pathways that mediate these functions are unresolved. Here
we report the identification of a specific association of Mdm2 with Mre11, Nbs1, and Rad50,
a DNA double strand break repair complex. Mdm2 bound to the Mre11-Nbs1-Rad50
complex in primary cells and in cells containing inactivated p53 or p14/p19 ARF, a regulator
of Mdm2. Further analysis revealed that Mdm2 directly bound to Nbs1 but not to Mre11 or …
