Longitudinal study of cytokine and immune transcription factor mRNA expression in septic shock
A Pachot, G Monneret, N Voirin, P Leissner, F Venet… - Clinical …, 2005 - Elsevier
Success in treating severe sepsis will require relevant tools to monitor the patient
immunoinflammatory status. This study aimed to investigate the feasibility of measuring a
panel of immunological mediator mRNAs in whole blood and to study their prognostic
values in septic shock patients. At the onset of shock, compared to healthy volunteers,
mRNA levels in septic shock patients were increased for IL-10, IL-1beta, and high mobility
group B1 (HMGB1) and decreased for transforming growth factor beta 1, the Th1, and Th2 …
immunoinflammatory status. This study aimed to investigate the feasibility of measuring a
panel of immunological mediator mRNAs in whole blood and to study their prognostic
values in septic shock patients. At the onset of shock, compared to healthy volunteers,
mRNA levels in septic shock patients were increased for IL-10, IL-1beta, and high mobility
group B1 (HMGB1) and decreased for transforming growth factor beta 1, the Th1, and Th2 …
