[HTML][HTML] The unfolded protein response modulates toxicity of the expanded glutamine androgen receptor
M Thomas, Z Yu, N Dadgar, S Varambally, J Yu… - Journal of Biological …, 2005 - ASBMB
Kennedy disease, a degenerative disorder caused by an expanded glutamine tract, is
mediated by misfolding of the mutant androgen receptor (AR) protein, a process that may
disrupt proteasome function. We hypothesized that this might lead to endoplasmic reticulum
(ER) stress and induction of the unfolded protein response (UPR), a complex physiologic
pathway that regulates cell survival. To test this hypothesis, we used aminoterminal
fragments of wild type (AR16Q) or mutant (AR112Q) AR that triggered glutamine length …
mediated by misfolding of the mutant androgen receptor (AR) protein, a process that may
disrupt proteasome function. We hypothesized that this might lead to endoplasmic reticulum
(ER) stress and induction of the unfolded protein response (UPR), a complex physiologic
pathway that regulates cell survival. To test this hypothesis, we used aminoterminal
fragments of wild type (AR16Q) or mutant (AR112Q) AR that triggered glutamine length …