Alveolar macrophage-derived cytokines induce monocyte chemoattractant protein-1 expression from human pulmonary type II-like epithelial cells
TJ Standiford, SL Kunkel, SH Phan, BJ Rollins… - Journal of Biological …, 1991 - ASBMB
Many acute and chronic lung diseases are characterized by the presence of increased
numbers of activated macrophages. These macrophages are derived predominantly from
newly recruited peripheral blood monocytes and may play a role in the amplification and
perpetuation of an initial lung insult. The process of inflammatory cell recruitment is poorly
understood, although the expression of inflammatory cell-specific chemoattractants and
subsequent generation of chemotactic gradients is likely involved. Although immune cells …
numbers of activated macrophages. These macrophages are derived predominantly from
newly recruited peripheral blood monocytes and may play a role in the amplification and
perpetuation of an initial lung insult. The process of inflammatory cell recruitment is poorly
understood, although the expression of inflammatory cell-specific chemoattractants and
subsequent generation of chemotactic gradients is likely involved. Although immune cells …