Migration of leukocytes from the bone marrow to the circulation, the primary lymphoid organs
and inflammatory sites is directed by chemokines and specific receptor interactions. Besides
the role of this group of low molecular weight cytokines in leukocyte attraction and activation,
anti-HIV and hematopoietic activities were also attributed to chemokines. On the basis of the
number and arrangement of the conserved cysteines, chemokines are subdivided in two
multi-member families, namely the CXC and CC chemokines, whereas fractalkine (CX3C) …