PINK1 displays tissue-specific subcellular location and regulates apoptosis and cell growth in breast cancer cells
A Berthier, S Navarro, J Jiménez-Sáinz, I Roglá… - Human pathology, 2011 - Elsevier
The PINK1 gene is mutated in the germ line of patients with hereditary early-onset Parkinson
disease, and PINK1 prosurvival function at neuronal mitochondria has been related with the
etiology of this disease. However, the expression and function of PINK1 protein in
nonneuronal tissues has not been determined yet. Here, we have analyzed PINK1 protein
expression and subcellular distribution in normal and neoplastic human tissues and
investigated the function of PINK1 in breast carcinoma cells. PINK1 protein, as stained by a …
disease, and PINK1 prosurvival function at neuronal mitochondria has been related with the
etiology of this disease. However, the expression and function of PINK1 protein in
nonneuronal tissues has not been determined yet. Here, we have analyzed PINK1 protein
expression and subcellular distribution in normal and neoplastic human tissues and
investigated the function of PINK1 in breast carcinoma cells. PINK1 protein, as stained by a …
