Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β converting enzyme
CA Ray, RA Black, SR Kronheim, TA Greenstreet… - Cell, 1992 - cell.com
CA Ray, RA Black, SR Kronheim, TA Greenstreet, PR Sleath, GS Salvesen, DJ Pickup
Cell, 1992•cell.comCowpox virus effectively inhibits inflammatory responses against viral infection in the chick
embryo. This study demonstrates that one of the viral genes necessary for this inhibition, the
crmA gene (a cytokine response modifier gene), encodes a serpin that is a specific inhibitor
of the interleukin-lb converting enzyme. This serpin can prevent the proteolytic activation of
interleukin-lp, thereby suppressing an interleukin-lf3 response to infection. However, the
modification of this single cytokine response is not sufficient to inhibit inflammatory …
embryo. This study demonstrates that one of the viral genes necessary for this inhibition, the
crmA gene (a cytokine response modifier gene), encodes a serpin that is a specific inhibitor
of the interleukin-lb converting enzyme. This serpin can prevent the proteolytic activation of
interleukin-lp, thereby suppressing an interleukin-lf3 response to infection. However, the
modification of this single cytokine response is not sufficient to inhibit inflammatory …
Summary
Cowpox virus effectively inhibits inflammatory responses against viral infection in the chick embryo. This study demonstrates that one of the viral genes necessary for this inhibition, the crmA gene (a cytokine response modifier gene), encodes a serpin that is a specific inhibitor of the interleukin-lb converting enzyme. This serpin can prevent the proteolytic activation of interleukin-lp, thereby suppressing an interleukin-lf3 response to infection. However, the modification of this single cytokine response is not sufficient to inhibit inflammatory responses. This suggests that cowpox virus encodes several cytokine response modifiers that act together to inhibit the release of proinflammatory cytokines in response to infection. These viral countermeasures to host defenses against infection may contribute significantly to the pathology associated with poxvirus infections.
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