[HTML][HTML] Mice lacking the sodium-dependent phosphate import protein, PiT1 (SLC20A1), have a severe defect in terminal erythroid differentiation and early B cell …
L Liu, M Sánchez-Bonilla, M Crouthamel… - Experimental …, 2013 - Elsevier
Phosphate is critical in multiple biological processes (phosphorylation reactions, ATP
production, and DNA structure and synthesis). It remains unclear how individual cells initially
sense changes in phosphate availability and the cellular consequences of these changes.
PiT1 (or SLC20A1) is a constitutively expressed, high-affinity sodium-dependent phosphate
import protein. In vitro data suggest that PiT1 serves a direct role in mediating cellular
proliferation; its role in vivo is unclear. We have discovered that mice lacking PiT1 develop a …
production, and DNA structure and synthesis). It remains unclear how individual cells initially
sense changes in phosphate availability and the cellular consequences of these changes.
PiT1 (or SLC20A1) is a constitutively expressed, high-affinity sodium-dependent phosphate
import protein. In vitro data suggest that PiT1 serves a direct role in mediating cellular
proliferation; its role in vivo is unclear. We have discovered that mice lacking PiT1 develop a …