[HTML][HTML] Differential gene expression profiling of primary cutaneous melanoma and sentinel lymph node metastases
SS Koh, JPJ Wei, X Li, RR Huang, NB Doan… - Modern Pathology, 2012 - Elsevier
Limited understanding of molecular mechanisms of metastasis in melanoma contributes to
the absence of effective treatments. Increased knowledge of alterations in genes that
underpin critical molecular events that lead to metastasis is essential. We have investigated
the gene expression profiles of primary melanomas and melanoma metastases in sentinel
lymph nodes. A total of 19 samples (10 primary melanomas and 9 sentinel lymph node
metastases) were evaluated. Melanoma cells were dissected from tissue blocks. Total …
the absence of effective treatments. Increased knowledge of alterations in genes that
underpin critical molecular events that lead to metastasis is essential. We have investigated
the gene expression profiles of primary melanomas and melanoma metastases in sentinel
lymph nodes. A total of 19 samples (10 primary melanomas and 9 sentinel lymph node
metastases) were evaluated. Melanoma cells were dissected from tissue blocks. Total …