[HTML][HTML] Fibrin but not adsorbed fibrinogen supports fibronectin assembly by spread platelets: Effects of the interaction of αIIbβ3 with the C terminus of the fibrinogen γ …
We investigated the assembly of soluble fibronectin by lysophosphatidic acid-activated
platelets adherent to fibrinogen or fibrin. More fibronectin was assembled by activated
platelets spread on fibrin matrices than by platelets spread on adsorbed fibrinogen. The
difference between platelets adherent to fibrinogen and fibrin occurred under both static and
flow conditions. Similar differences were seen in binding of the 70-kDa N-terminal fragment
of fibronectin that recognizes fibronectin assembly sites on adherent cells. Antibody and …
platelets adherent to fibrinogen or fibrin. More fibronectin was assembled by activated
platelets spread on fibrin matrices than by platelets spread on adsorbed fibrinogen. The
difference between platelets adherent to fibrinogen and fibrin occurred under both static and
flow conditions. Similar differences were seen in binding of the 70-kDa N-terminal fragment
of fibronectin that recognizes fibronectin assembly sites on adherent cells. Antibody and …