Design and synthesis of potent, non-peptidic inhibitors of HPTPβ
KKD Amarasinghe, AG Evidokimov, K Xu… - Bioorganic & medicinal …, 2006 - Elsevier
KKD Amarasinghe, AG Evidokimov, K Xu, CM Clark, MB Maier, A Srivastava, AO Colson…
Bioorganic & medicinal chemistry letters, 2006•ElsevierThe sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate
template to obtain highly selective and potent inhibitors of HPTPβ. Potentially hydrolyzable
malonate ester functionalities were replaced with 1, 2, 4-oxadiazoles without a significant
effect on HPTPβ potency.
template to obtain highly selective and potent inhibitors of HPTPβ. Potentially hydrolyzable
malonate ester functionalities were replaced with 1, 2, 4-oxadiazoles without a significant
effect on HPTPβ potency.
The sulfamic acid phosphotyrosine mimetic was coupled with a previously known malonate template to obtain highly selective and potent inhibitors of HPTPβ. Potentially hydrolyzable malonate ester functionalities were replaced with 1,2,4-oxadiazoles without a significant effect on HPTPβ potency.
Elsevier
