[HTML][HTML] Cyclic GMP-dependent protein kinase regulates the expression of thioredoxin and thioredoxin peroxidase-1 during hormesis in response to oxidative stress …
T Andoh, CC Chiueh, PB Chock - Journal of Biological Chemistry, 2003 - ASBMB
Human neuroblastoma cells, SH-SY5Y, contain relatively low levels of thioredoxin (Trx);
thus, they serve favorably as a model for studying oxidative stress-induced apoptosis
(Andoh, T., Chock, PB, and Chiueh, CC (2001) J. Biol. Chem. 277, 9655–9660). When these
neurotrophic cells were subjected to nonlethal 2-h serum deprivation, their neuronal nitric
oxide synthase and Trx were up-regulated, and the cells became more tolerant of oxidative
stress, indicating that NO may protect cells from serum deprivation-induced apoptosis. Here …
thus, they serve favorably as a model for studying oxidative stress-induced apoptosis
(Andoh, T., Chock, PB, and Chiueh, CC (2001) J. Biol. Chem. 277, 9655–9660). When these
neurotrophic cells were subjected to nonlethal 2-h serum deprivation, their neuronal nitric
oxide synthase and Trx were up-regulated, and the cells became more tolerant of oxidative
stress, indicating that NO may protect cells from serum deprivation-induced apoptosis. Here …
