[HTML][HTML] The mammalian chitinase-like lectin, YKL-40, binds specifically to type I collagen and modulates the rate of type I collagen fibril formation
HF Bigg, R Wait, AD Rowan, TE Cawston - Journal of Biological Chemistry, 2006 - ASBMB
YKL-40 is expressed in arthritic cartilage and produced in large amounts by cultured
chondrocytes, but its exact role is unclear, and the identities of its physiological ligands
remain unknown. Purification of YKL-40 from resorbing bovine nasal cartilage and
chondrocyte monolayers demonstrated the existence of three isoforms, a major and minor
form from resorbing cartilage and a third species from chondrocytes. Affinity chromatography
experiments with purified YKL-40 demonstrated specific binding of all three forms to …
chondrocytes, but its exact role is unclear, and the identities of its physiological ligands
remain unknown. Purification of YKL-40 from resorbing bovine nasal cartilage and
chondrocyte monolayers demonstrated the existence of three isoforms, a major and minor
form from resorbing cartilage and a third species from chondrocytes. Affinity chromatography
experiments with purified YKL-40 demonstrated specific binding of all three forms to …