Gene for the activating natural killer cell receptor, KIR2DS1, is associated with susceptibility to psoriasis vulgaris
W Łuszczek, M Mańczak, M Cisło, P Nockowski… - Human immunology, 2004 - Elsevier
Psoriasis vulgaris, particularly its juvenile form, is strongly associated with the HLA-Cw* 06
allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory
receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural
killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence
of particular KIR genes. We hypothesized that either activatory KIR2DS1 or inhibitory
KIR2DL1 gene frequencies might be different in psoriatic patients from a control population …
allele encoding the HLA-Cw6 molecule. This molecule is recognized by the inhibitory
receptor KIR2DL1 and the activatory receptor KIR2DS1, which are expressed on natural
killer cells and subpopulations of T lymphocytes. Humans differ by the presence or absence
of particular KIR genes. We hypothesized that either activatory KIR2DS1 or inhibitory
KIR2DL1 gene frequencies might be different in psoriatic patients from a control population …
