Hepatitis C virus and its pathogenesis
K Shimotohno - Seminars in cancer biology, 2000 - Elsevier
K Shimotohno
Seminars in cancer biology, 2000•ElsevierHepatitis C virus is a major causative agent of chronic hepatitis and the development of
hepatocellular carcinoma. However, the roles of this virus in these diseases remain to be
clarified, although it is likely that cytotoxic T lymphocytes (CTL) play crucial roles in the
clearance of virus-infected cells, thus causing inflammation. In many cases the clearance is
not sufficient to eradicate all infected cells. This may be due to insufficient activation of CTL.
In addition, it is also likely that the virus has some mechanism to escape from clearance …
hepatocellular carcinoma. However, the roles of this virus in these diseases remain to be
clarified, although it is likely that cytotoxic T lymphocytes (CTL) play crucial roles in the
clearance of virus-infected cells, thus causing inflammation. In many cases the clearance is
not sufficient to eradicate all infected cells. This may be due to insufficient activation of CTL.
In addition, it is also likely that the virus has some mechanism to escape from clearance …
Hepatitis C virus is a major causative agent of chronic hepatitis and the development of hepatocellular carcinoma. However, the roles of this virus in these diseases remain to be clarified, although it is likely that cytotoxic T lymphocytes (CTL) play crucial roles in the clearance of virus-infected cells, thus causing inflammation. In many cases the clearance is not sufficient to eradicate all infected cells. This may be due to insufficient activation of CTL. In addition, it is also likely that the virus has some mechanism to escape from clearance. One such mechanism may be the suppression of apoptosis by activation of NF-kB or mitogenic function by virus proteins, and these functions may also be linked to the development of hepatocellular carcinoma.
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