Tyrosine phosphorylation of IκBα activates NFκB through a redox-regulated and c-Src-dependent mechanism following hypoxia/reoxygenation
C Fan, Q Li, D Ross, JF Engelhardt - Journal of Biological Chemistry, 2003 - ASBMB
NFκB is a critical transcription factor involved in modulating cellular responses to
environmental injuries. Tyrosine 42 phosphorylation of IκBα has been shown to mediate
NFκB activation following hypoxia/reoxygenation (H/R) or pervanadate treatment. This
pathway differs from the canonical proinflammatory pathways, which mediate NFκB
activation through serine phosphorylation of IκBα by the IKK complex. In the present study,
we investigated the involvement of c-Src in the redox activation of NFκB following H/R or …
environmental injuries. Tyrosine 42 phosphorylation of IκBα has been shown to mediate
NFκB activation following hypoxia/reoxygenation (H/R) or pervanadate treatment. This
pathway differs from the canonical proinflammatory pathways, which mediate NFκB
activation through serine phosphorylation of IκBα by the IKK complex. In the present study,
we investigated the involvement of c-Src in the redox activation of NFκB following H/R or …
