Phosphorylation of src family lck tyrosine kinase following interleukin-12 activation of human natural killer cells
C Pignata, KVS Prasad, M Hallek, B Druker… - Cellular …, 1995 - Elsevier
Interleukin-12 (IL-12) is a heterodimeric cytokine that augments the cytolytic activity of
human NK cells and T cells but has little mitogenic activity on resting lymphocytes. The
intracellular signaling pathways involved in NK cell activation by IL-12 have not been fully
characterized. In the present studies we found that IL-12 induces tyrosine phosphorylation of
a 56-kDa protein, identified in Western blot experiments as p56lck, in resting NK cells. IL-12
was active in the range of 0.1 to 1000 U/ml, with maximal activity between 10 and 100 U/ml …
human NK cells and T cells but has little mitogenic activity on resting lymphocytes. The
intracellular signaling pathways involved in NK cell activation by IL-12 have not been fully
characterized. In the present studies we found that IL-12 induces tyrosine phosphorylation of
a 56-kDa protein, identified in Western blot experiments as p56lck, in resting NK cells. IL-12
was active in the range of 0.1 to 1000 U/ml, with maximal activity between 10 and 100 U/ml …